Analysis of Counterfeit Antidiabetic Drugs by UHPLC with the Agilent 1220 Infinity Mobile LC
نویسنده
چکیده
Counterfeiting in the pharmaceutical industry has become a serious and underreported problem, particularly in developing countries. This Application Note shows the analysis of antidiabetic drugs of the sulfonylurea class using the Agilent 1220 Infinity Gradient LC system with diode array detector (DAD). Both HPLC and UHPLC methods revealed excellent precision, accuracy and linearity as well as comparable limits of detection and quantification. With retention time and spectral confirmation, chemical antidiabetic substances could be identified and quantified in antidiabetic drugs and dietary supplements. Analysis of Counterfeit Antidiabetic Drugs by UHPLC with the Agilent 1220 Infinity Mobile LC
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